40 Hz Gamma frequency leads to the activation of microglia therefore ameliorates amyloid-β plaque, are there going to be adversely affect in terms of the neural activity. due to the GENUS can have
I just need to write out the hypothesis, proposed experiment, and possible results. No actual experiment needed.
I have a presentation in the attachment40 Hz Gamma frequency leads to the activation of microglia therefore ameliorates amyloid-β plaque (1)
Introduction
Alzheimer’s disease
Degenerative brain disease and the most common form of dementia.
Amyloid plaque
There are many treatments that target different aspect of the diseases.
Alzheimer’s disease is the most prevalent form of dementia
How does the amyloid plaque forms
Hydrolysis of Amyloid Precursor Protein
Microglia
A type of glia cell
Morphological shift
Activated by 40Hz brainwave.
Engulfing Amyloid-B protein
40Hz stimulation
Amyloid-B protein plaques in the
Mouse’s brain decreases compare with
non stimulated mouse.
Previous Morris Water Maze Result
Stimulated 5XFAD mouse took less time than the
other AD mouse.
Gamma Frequency
Non-invasive light flicker at 40 Hz
(Gamma ENtrainment Using Sensory stimulus, or GENUS)
In the experiment, Auditory stimulation (4)
20Hz
40Hz
80Hz
experiment — activate microglia to ameliorate amyloid plaque
Relative soluble Aβ1–42 levels in AC and HPC in 6-month-old 5XFAD mice following 40 Hz, 8 Hz, 80 Hz, or random auditory stimulation for 1 hr/day for 7 days (1-week)
40 Hz
Random
No Stimulation
Result of the experiment
It is showing improvement
Behavior experiments
Objection recognition index
Location recognition index
Escape latency
Can it improve cognitive function in AD remains to be determined
Retinal Ganglion Cells (RGCs)
&
The dorsal lateral geniculate nucleus (dLGN)
A retinal ganglion cell (RGC) is a type of neuron located near the inner surface (the ganglion cell layer) of the retina of the eye
Dorsal lateral geniculate nucleus receives a major sensory input from the retina
2nd part– Microglia and the developing synapses
Engulfment of RGC inputs is significantly increased during peak pruning in the dLGN (P5)
Engulfment in P5 dLGN occurs most significantly in …
Get Your Paper Before the Deadline. Our Services are 100% private and Confidential
Useful Links That Will Help You Around
Link to new order https://studentsolutionsusa.com/orders/stud/new
link to login page https://studentsolutionsusa.com/orders/login
New user registration link https://studentsolutionsusa.com/orders/register
Forgot Password https://studentsolutionsusa.com/orders/forgot/password
FREQUENTLY ASKED QUESTIONS
Question: How does this work?
Answer: Good Question. We are a group of a freelance board of students and professional essay writers. At our website, you may get help with any type of academic assignments: essay, coursework, term paper, business plan, case study, article review, research paper, presentation, and speech. Top writers can help with complex assignments such as dissertations, thesis papers, etc. All of them are professionals possessing excellent knowledge in their field of expertise, perfect writing skills, quality, and speed. When you place an order on our website, we assign it to the best writer. Once the writer finishes the work, the paper is submitted to our quality assurance desk who go through it and ensure it is unique and plagiarism free and that the instructions were followed to the detail. After this step we upload the paper in your account, we also send a copy to the email that you used to register the account with. we can guarantee you that the paper will be 100% plagiarism free. Besides, our services are 100% private and confidential
Question: How do I place an Order after getting to the order page
Answer: There are three major steps in the ordering process
Step 1 ....................................................paper details In this step, you will fill in the instructions of your paper; you can upload any materials that you feel will make your assignment a success. Besides, you can also email us at [email protected] Remember to specify the correct academic level. Please note that sources mean the number of references.
Step 2...................................................... Price calculation Kindly specify the number of pages, type of spacing and the correct deadline. This step will give you the estimated cost minus discount -- you may add the extra features if you wish.
Step 3 ....................................................discount and payment Use the discount code HAPPY2018 to enjoy up to 30% discount of your total cost After this step, proceed to safe payment; you can checkout using your card or PayPal Please note we will send the complete paper to the email you will provide while registering. A copy will also be uploaded to your account
Question: How will I know when my paper is complete? or How will I get the complete Paper?
Answer: Once we are done with the paper, we will be uploaded to your account. A copy will also be sent to the email you registered with. We can guarantee you the following:- 1. Our service is private and confidential; we don't spam or share your contacts with anyone 2. The final paper will be plagiarism free. We will send a Turnitin Report to the email you registered with 3. At our company, willing to do free unlimited revisions until you are satisfied with your paper
Question:- Am a new client, How can I get the guarantee that the paper will be completed and sent to me before my deadline?
Answer: Thank you for expressing your concerns. We would love to have you as our loyal customer. We are certain if we do good work, you will come back for me. Besides, you will give us referrals to your friends and family. For that reason, we can’t fail to deliver your paper within your specified time frame. We will ensure we submit the paper on time so that you can have enough time to go through it, if you have problems with the paper delivered, you can request a free revision. You are entitled to as many revisions as you would wish until you get a paper that satisfies you
Useful Links That Will Help You Around
Link to new order https://studentsolutionsusa.com/orders/stud/new
link to login page https://studentsolutionsusa.com/orders/login
New user registration link https://studentsolutionsusa.com/orders/register
Forgot Password https://studentsolutionsusa.com/orders/forgot/password
