1. What is the relationship between levels of CD4 lymphocytes and the likelihood of
clinical complications from AIDS?
2. Why does the United States Public Health Service recommend monitoring CD4 counts
every 3 to 6 months in patients infected with HIV?
answer all questions with a scholarly response using APA and include 2 scholarly references.
Copyright 2014 by Mosby, Inc., an imprint of Elsevier Inc.
Pagana: Mosby’s Manual of Diagnostic and Laboratory Tests, 5th Edition
AIDS (Acquired Immunodeficiency Syndrome)
Case Studies
The patient, a 30-year-old homosexual man, complained of unexplained weight loss, chronic
diarrhea, and respiratory congestion during the past 6 months. Physical examination revealed
right-sided pneumonitis. The following studies were performed:
Studies Results
Complete blood cell count (CBC), p. 174
Hemoglobin (Hgb), p. 259 12 g/dL (normal: 14-18 g/dL)
Hematocrit (Hct), p. 256 36% (normal: 42%-52%)
Chest X-ray, p. 1014 Right-sided consolidation affecting the posterior
lower lung
Bronchoscopy, p. 587 No tumor seen
Lung biopsy, p. 738 Pneumocystis jiroveci pneumonia (PCP)
Stool culture, p. 855 Cryptosporidium muris
Acquired immunodeficiency syndrome
(AIDS) serology, p. 297
p24 antigen Positive
Enzyme-linked immunosorbent assay
(ELISA)
Positive
Western blot Positive
Lymphocyte immunophenotyping, p. 306
Total CD4 280 (normal: 600-1500 cells/L)
CD4% 18% (normal: 60%-75%)
CD4/CD8 ratio 0.58 (normal: >1.0)
Human immune deficiency virus (HIV)
viral load, p. 297
75,000 copies/mL
Diagnostic Analysis
The detection of Pneumocystis jiroveci pneumonia (PCP) supports the diagnosis of AIDS.
PCP is an opportunistic infection occurring only in immunocompromised patients and is the
most common infection in persons with AIDS. The patient’s diarrhea was caused by
Cryptosporidium muris, an enteric pathogen, which occurs frequently with AIDS and can be
identified on a stool culture. The AIDS serology tests made the diagnoses. His viral load is
significant, and his prognosis is poor.
The patient was hospitalized for a short time for treatment of PCP. Several months after he
was discharged, he developed Kaposi sarcoma. He developed psychoneurologic problems
eventually and died 18 months after the AIDS diagnosis.
Case Studies 2
Copyright 2014 by Mosby, Inc., an imprint of Elsevier Inc.
Critical Thinking Questions
1. What is the relationship between levels of CD4 lymphocytes and the likelihood of
clinical complications from AIDS?
2. Why does the United States Public Health Service recommend monitoring CD4 counts
every 3 to 6 months in patients infected with HIV?
